How do we cope with loss and grief?

© Bevin Christina Dunn

Why do some people experience more intense, persistent and prolonged grief?

Mary-Frances O’Connor conducts studies to better understand the grief process both psychologically and physiologically. She is a leader in the field of prolonged grief, a clinical condition in which people do not adjust to the acute feelings of grief and show increases in yearning, avoidance, and rumination. Her work primarily focuses on trying to tease out the mechanisms that cause this ongoing and severe reaction to loss. In particular, she is curious about the neurobiological, immune, and cardiovascular factors that vary between individual responses to grief.


The Grieving Brain: The Surprising Science of How We Learn from Love and Loss

Available everywhere books are sold

Mary-Frances shares groundbreaking discoveries about what happens in our brain when we grieve, providing a new paradigm for understanding love, loss, and learning.


How do our brains handle grief?

TEDxUArizona

In this independently organized TEDx event, Mary-Frances discusses how the human brain can create new pathways in order to learn what life is like after we experience a loss and become someone who carries both grief and the absence of another.

Key Publications